The Uptake of Fibrin and Fibrin-Degradation Products by the Isolated Perfused Rat Liver

The uptake of fibrin and fibrin-degradation products by the isolated perfused rat liver.

Fibrinogen-fibrin degradation products.

The identification of the molecular structure of fibrinogen has given a better understanding of many clinical conditions associated with abnormalities of fibrinogen. Proteolysis of fibrinogen or fibrin by its natural lytic enzyme, plasmin, leads to the formation of degradation products which are of great importance in the laboratory diagnosis of many pathological conditions. The biochemical and...

Uptake of free choline by isolated perfused rat liver.

The uptake of free choline by isolated perfused rat liver was characterized. A saturable uptake mechanism [Ka = 0.17 +/- 0.07 mM (SD); Vmax = 0.84 +/- 0.16 mumol/min X g dry weight] and a nonsaturable mechanism (through which uptake is proportional to choline concentration in the perfusate) were identified. Most of the choline transported into hepatocytes was converted to betaine, phosphorylcho...

Menstrual blood loss and fibrin degradation products.

As part of a large-scale study of menstrual blood loss in the community serum fibrin degradation products were measured soon after menstruation in 331 women. No significant correlation was found between the amount of blood lost and the serum level of fibrin degradation products. These findings conflict with reports suggesting that excessive intrauterine fibrinolysis, which may play a part in me...

Fibrin degradation products and ovarian tumours.

Fibrin degradation products (F.D.P.) were determined in the serum of 163 women in whom ovarian tumours had been suspected on palpation at gynaecological examination and who were afterwards examined by laparoscopy or subjected to laparotomy. F.D.P. were found in the serum (0.5-30 mg/100 ml) of 23 (72%) out of 32 patients with malignant tumours. Of 131 patients with benign findings F.D.P. (traces...